HCID 19972023, compound → HCID 19972018, compound

HRID 975489Notes

Reaction equation

HRID 975489 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([P:11]([CH:21](Br)[NH:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])(=[O:20])[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)Br)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:31]1([Mg]Cl)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:1]([O:5][C:6]([NH:8][CH:9]([P:11]([CH:21]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[NH:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])(=[O:20])[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 19972023HCID 19972023, compoundHCID 178478979HCID 178478979, compound

Product 1

HCID 19972018HCID 19972018, compoundYield 32%

Procedure

In analogy to Example 11, the benzyl phosphinate 12 is prepared from the bis-substituted benzyl bromophosphinate 8 and a 2.0N phenylmagnesium chloride solution in a yield of 32%.

Sources & evidence

ORD record
ord-8401af28b19b46b1bfd494d817e44d52
Source dataset
uspto-grants-1997_03
Patent number
US05608098

Reaction notes

Loading…