(-)-Menthol → HCID 15346410, compound

Participants

Reaction Steps

That is, (2S)-3-l-menthoxypropane-1,2-diol can be obtained by adding (1R, 2S, 5R)-5-methyl-2-(1-methylethyl)cyclohexyl alcohol (hereinafter, is referred to as "l-menthol") to (R)-(-)-benzyl glycidyl ether [the compound of formula (II)]in the presence of a Lewis acid catalyst to provide (2S)-1-benzyloxy-2-hydroxy-3-{(1R, 2S, 5R)-[5-methyl-2-(1-methylethyl)cyclohexyl]oxy}propane [the compound of formula (III)], and hydrogenolyzing the compound in the presence of a palladium-carbon catalyst to eliminate the benzyl group.

Provenance & Evidence