HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitroimidazole → N-(4-Methylpent-3-en-1-yl)-2-nitroimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitroimidazole | HCID 10701 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-2-methyl-2-pentene | HCID 137521 | — |
| Product | N-(4-Methylpent-3-en-1-yl)-2-nitroimidazole | HCID 15186012 | — |
Reaction Steps
5-Bromo-2-methyl-2-pentene (15 g, 0.092 mol) was added to a slurry of 2-nitroimidazole (10.4 g, 0.092 mol) and potassium carbonate (12.7 g, 0.092 mol) and refluxed for 24 hrs. Acetone was removed on a rotary evaporator and the residue was purified by column chromatography. Yield 6.2 g (34%). 1H NMR CDCl3) δ1.44 and 1.68 [s, 6H, =C(CH3)2 ], 2.53 (m, t 2H, CH2CH2CN<), 4.41 (t, 2H, CH2CH2CN<), 5.06 (m, 1H, CH=C), 7.03 and 7.12 (s, 2H, imi H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05608110 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-cf9daa59692f4991abcb22dcaa3d834c |
| Source note | uspto-grants-1997_03 |