Methanol → 4-Hydroxy-L-proline methyl ester hydrochloride

Participants

Reaction Steps

Acetyl chloride (380 ml) was dropwise added to methanol (3.5 l) at 10°-25° C. with stirring, followed by (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid (500 g). The mixture was refluxed for 3 hours. The mixture was cooled to the ambient temperature and poured into diethyl ether to give precipitates. The precipitates were collected by filtration and dried up in vacuo to give methyl (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylate hydrochloride (676 g).

Provenance & Evidence