Water → HCID 57010773, compound

Participants

Reaction Steps

To a solution of (2S,4R)-1-allyloxycarbonyl-2-(4-formyl-2-oxopiperazin-1-yl) methyl-4-hydroxypyrrolidine (11.38 g) in ethyl acetate (110 ml) were added triethylamine (5.6 ml) and methanesulfonyl chloride (3.11 ml) under ice-cooling with stirring, and the mixture was stirred at the same temperature for 1 hour. To the mixture was added water and the mixture was evaporated in vacuo. To the residue was added tetrahydrofuran, and the mixture was stirred at 50° C. for 20 minutes. The mixture was filtered and the filtrate was dried over anhydrous magnesium sulfate, and evaporated in vacuo to give (2S,4R)-1-allyloxycarbonyl-2-(4-formyl-2-oxopiperazin-1-yl) methyl-4-(methanesulfonyloxy)pyrrolidine (14.2 g).

Provenance & Evidence