Hydrochloric Acid → HCID 54136579, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S,4R)-1-allyloxycarbonyl-2-(4-formyl-2-oxopiperazin-1-yl) methyl-4-(methanesulfonyloxy)pyrrolidine (14.2 g) in methanol (60 ml) was added conc. hydrochloric acid (12.2 ml) under ice cooling with stirring, and the mixture was stirred at the same temperature for 10 hours. The mixture was cooled to 5° C. and 28% sodium methoxidemethanol solution (28.2 ml) was added to it. The mixture was filtered, and the filtrate was evaporated in vacuo. To the residue was added chloroform. The mixture was dried over anhydrous magnesium sulfate and evaporated in vacuo to give (2S,4R)-1-allyloxycarbonyl-2-(2-oxopiperazin-1-yl) methyl-4-(methanesulfonyloxy)pyrrolidine (6.54 g).

Provenance & Evidence