HCID 67705713, compound → HCID 54141268, compound

Participants

Reaction Steps

To a Raney-Nickel (NDT-90, 1400 ml) was added 1-{(2S,4R)-1-benzyl-4-(t-butyldimethylsilyloxy) pyrrolidin-2-yl}-1-(1-methyl-2-thiophenylimidazol-5-yl)methanol (222 g) in ethanol (4.4 l) under an atmosphere of nitrogen. The mixture was stirred and heated under reflux for 2.5 hours. After cooling, the Raney-Nickel was removed by filtration and washed with ethanol (1 l×5). The filtrate and the washings were combined, dried over magnesium sulfate, evaporated in vacuo to give 1-{(2S,4R)-1-benzyl-4-(t-butyldimethylsilyloxy) pyrrolidin-2-yl}-1-(1-methylimidazol-5-yl)methanol (133.4 g) as an amorphous solid.

Provenance & Evidence