Hydrogen Peroxide → HCID 67705629, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2R,4S)-1-allyloxycarbonyl-2-cyanomethyl-4-(triphenylmethylthio) pyrrolidine (1.17 g) in dimethyl sulfoxide (3.75 ml) were added potassium carbonate (50 mg) and 30% hydrogen peroxide (313 μl). After stirring at 60° C. for 2 hours, the mixture was poured into a mixture of ethyl acetate and water. The separated organic layer was washed with aqueous sodium chloride solution twice, dried over magnesium sulfate and evaporated. The residue was subjected to column chromatography on silica gel (eluent; n-hexane:ethyl acetate=1:1) to give (2R,4S)-1-allyloxycarbonyl-2-carbamoylmethyl-4-(triphenylmethylthio)pyrrolidine (0.93 g).

Provenance & Evidence