Methyl iodide → HCID 57036803, compound

Participants

Reaction Steps

To a solution of (2R,4S)-1-allyloxycarbonyl-2-thiocarbamoylmethyl-4-(triphenylmethylthio) pyrrolidine (110 mg) in acetonitrile (4 ml) were added iodomethane (497 mg) and potassium carbonate (61 mg). After stirring at room temperature for 3 hours, the solution was poured into a mixture of ethyl acetate and water. The separated organic layer was washed with aqueous sodium chloride solution, dried over magnesium sulfate and evaporated. The residue was subjected to column chromatography on silica gel (eluent; n-hexane:ethyl acetate=3:2) to give (2R,4S)-1-allyloxycarbonyl-2-(2-imino-2-methylthioethyl)-4(triphenylmethylthio) pyrrolidine (72 mg).

Provenance & Evidence