Ammonia → HCID 22870381, compound

Participants

Reaction Steps

To a solution of (2R,4S)-1-allyloxycarbonyl-2-(2-azidoethyl)-4-(triphenylmethylthio) pyrrolidine (10.1 g) in pyridine (30 ml) was added triphenylphosphine at ambient temperature. The mixture was stirred at the same temperature for 1 hour, and then 28% aqueous ammonia was added. After stirring at ambient temperature overnight, the mixture was evaporated under reduced pressure, and co-evaporated with toluene. The residue was column chromatographed on silica gel (chloroform:methanol=9:1) to give (2R,4S)-1-allyloxycarbonyl-2-(2-aminoethyl)-4(triphenylmethylthio)pyrrolidine (9.0 g).

Provenance & Evidence