Potassium tert-butoxide → HCID 86750465, compound

HRID 975707Notes

Reaction equation

HRID 975707 reaction equation
[CH2:1]([O:4][C:5]([N:7]1[CH2:11][C@H:10](OS(C)(=O)=O)[CH2:9][C@H:8]1[CH2:17][CH2:18][N:19]1[CH:23]=[C:22]([CH2:24][C:25](=[O:27])[NH2:26])[N:21]=[CH:20]1)=[O:6])[CH:2]=[CH2:3].[C:28]([OH:36])(=[S:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.CC(C)([O-])C.[K+]>>[CH2:1]([O:4][C:5]([N:7]1[CH2:11][C@@H:10]([S:35][C:28](=[O:36])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:9][C@H:8]1[CH2:17][CH2:18][N:19]1[CH:23]=[C:22]([CH2:24][C:25](=[O:27])[NH2:26])[N:21]=[CH:20]1)=[O:6])[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 23665647Potassium tert-butoxideHCID 86750466HCID 86750466, compoundHCID 178526132HCID 178526132, compound

Product 1

HCID 86750465HCID 86750465, compound

Procedure

(2R,4R)-1-Allyloxycarbonyl-2-{2-(4-carbamoylmethyl-imidazol-1-yl) ethyl}-4-methanesulfonyloxypyrrolidine (2.74 g) were reacted with thiobenzoic acid (1.69 ml) and potassium t-butoxide (1.54 g) in substantially the same manner as Preparation 19-2) to give (2R,4S)-1-allyloxycarbonyl-4-benzoylthio-2-[2-(4-carbamoylmethyl-imidazol-1-yl) ethyl]pyrrolidine (2.30 g) as a yellow solid.

Workup

  1. customas Preparation 19-2)

Sources & evidence

ORD record
ord-c3b528d8884d484c97145e513dd2f407
Source dataset
uspto-grants-1997_03
Patent number
US05608056

Reaction notes

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