Methyl iodide →

Participants

Reaction Steps

To a solution of allyl (4R,5S,6S)-3-[(2R,4S)-1-allyloxycarbonyl-2-(1-methylimidazol-2-ylmethyl)-pyrrolidin-4-yl]thio-6-[(1R)-1-hydroxyethyl ]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (1.25 g) in acetone (12 ml) was added methyl iodide (1.47 ml ) at room temperature. The mixture was stirred for 35 hours at the same temperature. The reaction mixture was evaporated in vacuo to give allyl (4R,5S,6S)-3-[(2R,4S)-1-allyloxycarbonyl-2-(1, 3-dimethyl-2-imidazoliomethyl)-pyrrolidin-4-yl]thio-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate iodide (1.49 g) as an amorphous solid.

Provenance & Evidence