HRID975721

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCOC(=O)N1C[C@@H](SC(C)=O)C[C@H]1CCn1cncc1CO

HCID54235556

未命名化合物

结构：C=CCOC(=O)C(=[N+]=[N-])C(=O)[C@H](C)[C@H]1NC(=O)[C@@H]1[C@@H](C)O

HCID54331596

未命名化合物

PRODUCTS

生成物

结构：C=CCOC(=O)C1=C(S[C@H]2C[C@@H](CCn3cncc3CO)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12

HCID57072749

未命名化合物

收率 59.6%

PROCEDURE

实验过程

Allyl (4R)-2-diazo-4-[(2R,3S)-3-{(1R)-1-hydroxyethyl}-4-oxoazetidin-2-yl]-3-oxopentanoate (709 mg) and (2R,4S)-4-acetylthio-1-allyloxycarbonyl-2-[2-(5-hydroxymethylimidazol-1-yl) ethyl]pyrrolidine (849 mg) were reacted in substantially the same manner as that of Example 2-3) to give allyl (4R,5S,6S)-3-[(2R,4S)-1-allyloxycarbonyl-2-{2-(5-hydroxymethylimidazol-1-yl)ethyl}pyrrolidin-4-yl]thio-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (802 mg) as a yellow solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d665bc5367134d94b6de5734032ba8fb
来源数据集: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05608056
来源说明: uspto-grants-1997_03

反应 SMILES

[N+](=[C:3]([C:10](=O)[C@@H:11]([C@@H:13]1[C@@H:16]([C@H:17]([OH:19])[CH3:18])[C:15](=[O:20])[NH:14]1)[CH3:12])[C:4]([O:6][CH2:7][CH:8]=[CH2:9])=[O:5])=[N-].C([S:25][C@@H:26]1[CH2:30][N:29]([C:31]([O:33][CH2:34][CH:35]=[CH2:36])=[O:32])[C@H:28]([CH2:37][CH2:38][N:39]2[C:43]([CH2:44][OH:45])=[CH:42][N:41]=[CH:40]2)[CH2:27]1)(=O)C>>[CH2:34]([O:33][C:31]([N:29]1[CH2:30][C@@H:26]([S:25][C:10]2[C@H:11]([CH3:12])[C@H:13]3[N:14]([C:15](=[O:20])[C@@H:16]3[C@H:17]([OH:19])[CH3:18])[C:3]=2[C:4]([O:6][CH2:7][CH:8]=[CH2:9])=[O:5])[CH2:27][C@H:28]1[CH2:37][CH2:38][N:39]1[C:43]([CH2:44][OH:45])=[CH:42][N:41]=[CH:40]1)=[O:32])[CH:35]=[CH2:36]