Methyl triflate → HCID 86750487, compound

Participants

Reaction Steps

To a solution of allyl (4R,5S,6S)-3-[(2R,4S)-1-allyloxycarbonyl-2-{2-(4-cyanoimidazol-1-yl)ethyl}-pyrrolidin-4-yl]thio-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (7.56 g) in dichloromethane (110 ml) was added methyl trifluoromethanesulfonate (3.1 ml) at room temperature and the solution was stirred at the same temperature for 30 minutes. The solvent was evaporated to give allyl (4R,5S,6S)-3-[(2R,4S)-1-allyloxycarbonyl-2-{2-(4-cyano-3-methyl-1-imidazolio)ethyl}pyrrolidin-4-yl]thio-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate trifluoromethanesulfonate (10.4 g) as a yellow paste. This compound was immediately used as the starting compound for the next step.

Provenance & Evidence