Methanol → HCID 11795796, compound

Participants

Reaction Steps

A stirred mixture of 4 g (9.45 mmol) of methyl 8-(t-butoxycarbonyl)-1-cyclohexylmethyl-4-keto-1,3,8-triazaspiro [4.5]decan-3-acetate, 4 g (72 mmol) carbonate 60 ml of methanol and 40 ml of water was heated at reflux for 3 hours. The resulting solution was concentrated to about one-half of its original volume and then it was carefully acidified with 2N HCl at 0° C. The resulting mixture was extracted with ethyl acetate. After the extracts were dried over magnesium sulfate, they were concentrated. The residue solid was recrystallized from hexane to give the product as 2.75 g (69.5%) of colorless crystals, mp 148°-149° C.

Provenance & Evidence