Dimethylformamide → HCID 22870564, compound

Participants

Reaction Steps

1.5 g of (S)-3-amino-4-oxo-5-(p-isopropylbenzyl)-2,3,4,5-tetrahydro-1,5-benzoxazepine hydrochloride, 2.93 g of (R)-alpha-[[(4-nitrophenyl)sulfonyl]oxy]-4-cyclohexylbutyric acid ethyl ester (Helv. Chim. Acta 71 (2), 337, 1988), 1.85 ml of N-methylmorpholine and 2 ml of dimethylformamide are heated at 75° C. for 3 days. The reaction mixture is concentrated and separated by means of flash chromatography (230 g of silica gel, eluant hexane/ethyl acetate 4:1). The product is obtained in the form of a colourless resin. Rf value (eluant hexane/ethyl acetate 4:1): 0.36.

Provenance & Evidence