HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(1H-indol-4-yl)-piperazin-1-yl]-2-phenyl-butan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(piperazin-1-yl)-1H-indole | HCID 594590 | — |
| Reactant | 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-4-chloro-2-phenyl-butan-1-one | HCID 19968360 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(1H-indol-4-yl)-piperazin-1-yl]-2-phenyl-butan-1-one | HCID 19968364 | — |
Reaction Steps
The title compound was prepared from 4-(1H-indol-4-yl)-piperazine (1.0 g, 4.97 mmole), 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-chloro-2-phenyl-butan-1-one (1.6 g, 4.97 mmole), diisopropylethylamine (0.65 g, 4.97 mmole) and potassium iodide (0.83 g, 4.97 mmole) in dimethylformamide (8 mL) in the manner described in example 2 to yield 0.6 g of product as the hydrochloride 0.75 hydrate, m.p. 150°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05610154 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-3a211349bf5543509552ecfe9890c20e |
| Source note | uspto-grants-1997_03 |