Potassium Iodide → 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-2-phenyl-butan-1-one

Participants

Reaction Steps

The title compound was prepared from 4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine 0.7 g, 2.3 mmole, prepared according to the method reported in example 2), 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-chloro-2-phenyl-butan-1-one (0.7 g, 2.3 mmole), diisopropylethylamine (0.4 g, 3.0 mmole) and potassium iodide (0.5 g, 3.0 mmole) in dimethylformamide (25 mL) in the manner described in example 2 to yield 0.8 g of title product as the hydrochloride hemihydrate, m.p. 198°-199° C.

Provenance & Evidence