Hydrochloric Acid → 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-2-phenyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butan-1-one

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Reaction Steps

The title compound was prepared from 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine (0.9 g, 3.9 mmole), 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-chloro-2-phenyl-butan-1-one (1.6 g, 5.50 mmole), diisopropylethylamine (0.7 g, 5.4 mmole) and potassium iodide (0.8 g, 4.8 mmole) in dimethylformamide (30 mL) in the manner described in example 2 to yield 0.47 g of title product as the hydrochloride 0.3 hydrate, solid foam, m.p. 85°-120° C., (dec.).

Provenance & Evidence