Sulfuric Acid → HCID 19968441, compound

Participants

Reaction Steps

5-(4-Chlorophenyl)-5-hydroxy-1-azaspiro[5.5]undecane (5.9 g, prepared as described in Example C) was dissolved in concentrated sulphuric acid (75 ml) and stirred at ambient temperature for 3 hours. The mixture was then poured slowly into ice-water (300 ml) and the resulting solid collected by filtration, washed with a little water and dried in vacuo at ambient temperature over phosphorus pentoxide to give 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene sulphate as a white solid. Yield 6.2 g, mp 228°-233° C.

Provenance & Evidence