HCID 19968441, compound → HCID 10220867, compound

HRID 975828Notes

Reaction equation

HRID 975828 reaction equation
S(O)(O)(=O)=O.[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]3([CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[NH:17][CH2:16][CH2:15][CH:14]=2)=[CH:9][CH:8]=1>O>[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]3([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[NH:17][CH2:16][CH2:15][CH:14]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 19968441HCID 19968441, compound

Product 1

HCID 10220867HCID 10220867, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene sulphate (0.5 g, prepared as described in Example 5) and water (5 ml) was stirred at ambient temperature to give, initially, a mobile suspension which rapidly thickened. Water (5 ml) was added to aid mobility and the solid was collected by filtration, washed with water (5 ml) and dried in vacuo at ambient temperature to give 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene 0.5 sulphate, 2.1 hydrate as a white solid. Yield 0.3 g, mp 205°-215° C.

Workup

  1. customto give
  2. filtrationthe solid was collected by filtration
  3. washwashed with water (5 ml)
  4. customdried in vacuo at ambient temperature

Sources & evidence

ORD record
ord-a5d880275bbe46b8bbafc0240e40e2b8
Source dataset
uspto-grants-1997_03
Patent number
US05610161

Reaction notes

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