Fumaric Acid → HCID 19968435, compound

Participants

Reaction Steps

A solution of fumaric acid (0.4 g) in methanol (35 ml) was added to a solution of 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene (1.0 g, prepared in a similar manner to that described in Example 14) in ether (25 ml). The solvents were removed in vacuo and the residue was triturated with ether to yield a white solid, which was collected by filtration and dried in vacuo at ambient temperature to give 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene fumarate as a white solid. Yield 1.1 g, mp 175°-180.5° C. (dec).

Provenance & Evidence