Sulfuric Acid → HCID 19968399, compound

Participants

Reaction Steps

10-(4-Chlorophenyl)-10-hydroxy-6-azaspiro[4.5]decane (1.6 g) was dissolved in concentrated sulphuric acid (18 ml) and stirred at ambient temperature for 1.5 hours. The mixture was poured cautiously onto ice-water (35 ml), stirred at 0° C. for 1 hour and allowed to stand at 4° C. for 24 hours. The product was collected by filtration, washed with water and dried in vacuo at ambient temperature to give 10-(4-chlorophenyl)-6-azaspiro[4.5]dec-9-ene sulphate as an off-white solid. Yield 1.7 g, mp 184°-190° C.

Provenance & Evidence