反应详情

A mixture of 6.2 g of 6-[(5-fluoro-2-methylbenzoyl)amino]pyridine-3-carboxylic acid and 23 ml of thionyl chloride is refluxed for 1 hour. An additional 12 ml of thionyl chloride is added and the mixture refluxed for 0.5 hour. The mixture is concentrated to dryness under vacuum and 30 ml of toluene added to the residue. The toluene is removed under vacuum and the process (add toluene and remove) is repeated to give 7.7 g of crude product as a solid.

1. temperatureis refluxed for 1 hour
2. temperaturethe mixture refluxed for 0.5 hour
3. concentrationThe mixture is concentrated to dryness under vacuum and 30 ml of toluene
4. additionadded to the residue
5. customThe toluene is removed under vacuum
6. additionthe process (add toluene and remove)