HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-{[(3-Methylphenyl)carbamoyl]amino}acetic acid → HCID 131719904, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-{[(3-Methylphenyl)carbamoyl]amino}acetic acid | HCID 14996960 | — |
| Reactant | HCID 131719905 | HCID 131719905 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | HCID 131719904 | HCID 131719904 | — |
Reaction Steps
By proceeding in a fashion similar to that described in Example 1, but starting from 2 g of cyclopropyl-methyl (2RS,5SR)-5-phenylprolinate, 1.7 g of 2-[3-(3-methylphenyl)ureido]acetic acid in suspension in 50 cm3 of anhydrous 1,2-dichloroethane and 0.6 cm3 of sulphinyl chloride, 1.1 g of cyclopropylmethyl (2RS,5SR)-1-{2-[3-(3-methylphenyl)ureido}acetyl-5-phenylprolinate, melting at 130° C., are obtained after recrystallization in acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05610144 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-dbbde238d4b649568f15be3483c1cec7 |
| Source note | uspto-grants-1997_03 |