Potassium Hydroxide → HCID 54492825, compound

HRID 975955Notes

Reaction equation

HRID 975955 reaction equation
[C:1]1([C@H:7]2[CH2:11][CH2:10][C@@H:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:8]2[C:18](=[O:35])[CH2:19][NH:20][C:21](=[O:34])[NH:22][C:23]2[CH:24]=[C:25]([CH:31]=[CH:32][CH:33]=2)[C:26]([O:28]CC)=[O:27])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>CO.O>[C:12]1([C@H:9]2[CH2:10][CH2:11][C@@H:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[N:8]2[C:18](=[O:35])[CH2:19][NH:20][C:21](=[O:34])[NH:22][C:23]2[CH:24]=[C:25]([CH:31]=[CH:32][CH:33]=2)[C:26]([OH:28])=[O:27])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 54542287HCID 54542287, compound

Product 1

HCID 54492825HCID 54492825, compoundYield 70.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

By proceeding in a fashion similar to that described in Example 9, but starting from 3 g of ethyl (cis)-3-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoate in solution in 50 cm3 of methanol and 0.7 g of potassium hydroxide dissolved in 20 cm3 of water and after treatment and recrystallization in ethanol, 2 g of (cis)-3-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid, melting at 255° C., are obtained.

Workup

  1. customafter treatment and recrystallization in ethanol

Sources & evidence

ORD record
ord-52a420000f194f529d9be78b58560127
Source dataset
uspto-grants-1997_03
Patent number
US05610144

Reaction notes

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