HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 19968176, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 19967954 | HCID 19967954 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | m-Tolyl isocyanate | HCID 69303 | — |
| Product | HCID 19968176 | HCID 19968176 | — |
Reaction Steps
By proceeding in a fashion similar to that described in Example 2, but starting from 1.9 g of (2RS,5SR)-1-(2-aminoacetyl)-5-phenyl-N-tert-butylprolinamide in solution in 20 cm3 of anhydrous tetrahydrofuran and 0.82 cm3 of 3-methylphenyl isocyanate, after recrystallistion in acetonitrile, 0.7 g of (2RS,5SR)-N-tert-butyl-1-[3-(3-methylphenyl)ureidoacetyl]-5-phenylprolinamide, melting at 169° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05610144 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-c5f153e4edc8483385e2e98c2c54fa9a |
| Source note | uspto-grants-1997_03 |