Potassium Hydroxide → HCID 67713311, compound

HRID 975974Notes

Reaction equation

HRID 975974 reaction equation
[C:1]1([C@H:7]2[CH2:11][CH2:10][C@@H:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:8]2[C:18](=[O:37])[CH2:19][NH:20][C:21](=[O:36])[NH:22][C:23]2[CH:24]=[C:25]([CH2:29][CH2:30][C:31]([O:33]CC)=[O:32])[CH:26]=[CH:27][CH:28]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>CO.O>[C:12]1([C@H:9]2[CH2:10][CH2:11][C@@H:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[N:8]2[C:18](=[O:37])[CH2:19][NH:20][C:21](=[O:36])[NH:22][C:23]2[CH:24]=[C:25]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])[CH:26]=[CH:27][CH:28]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 67713285HCID 67713285, compound

Product 1

HCID 67713311HCID 67713311, compoundYield 19.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

By proceeding in a fashion similar to that described in Example 9, but starting from 4.8 g of ethyl cis-3-{3-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}-phenyl}propionate in solution in 25 cm3 of methanol and 0.25 g of potassium hydroxide dissolved in 5 cm3 of water and after treatment, 0.9 g of cis-3-{3-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenyl}propionic acid, melting at 170° C., is obtained.

Sources & evidence

ORD record
ord-ac4a043103c74bd7a3454c7239025a53
Source dataset
uspto-grants-1997_03
Patent number
US05610144

Reaction notes

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