Potassium Bromide → Potassium Hydroxide

Participants

Reaction Steps

By proceeding in a fashion similar to that described in Example 9, but starting from 4 g of benzyl cis-4-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetate in solution in 65 cm3 of methanol and 0.61 g of potassium hydroxide in solution in 12 cm3 of water, and after treatment, 1.8 g of cis-4-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetic acid, melting at 221° C., are obtained [proton NMR (200 MHz, DMSO D6, δ in ppm), 1.4 to 2.4 (m, 4H, CH2 --CH2); 3.3 (s, 2H, CH2CO2); 3.2 and 3.8 (ABX, 2H, CH2NH); 5.1 (m, 2H, 2 CHN); 6.1 (t, 1H exchangeable, NH); 6.9 (d, 2H, aromatic in para position); 7.1 to 7.4 (m, 12H, aromatic); 8.6 (s, 1H exchangeable, NH)], [infrared spectrum (KBr), characteristic bands in cm-1 3375, 3095, 3070, 3035, 2980, 2880, 1735, 1700, 1630, 1610, 1515, 1450, 1560, 805, 760, 705].

Provenance & Evidence