HCID 86750538, compound → HCID 19968058, compound

Participants

Reaction Steps

By proceeding in a fashion similar to that described in Example 9, but starting from 3.5 g of methyl (2RS,5SR)-3-{3-{2-[2-(2-methylphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetate in solution in 60 cm3 of methanol and 0.56 g of potassium hydroxide in solution in 11 cm3 of water, and after treatment and recrystallization in ethyl acetate, 2.2 g of (2RS,5SR)-3-{3-{2-[2-(2-methylphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetic acid, melting at 133° C., are obtained.

Provenance & Evidence