HCID 86750539, compound → HCID 57129201, compound

Participants

Reaction Steps

By proceeding in a fashion similar to that described in Example 9, but starting from 1.8 g of ethyl (2RS,5SR)-3-{3-{2-[2-(3-hydroxyphenyl)-5-(3-methoxyphenyl)-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoate in solution in 30 cm3 of methanol and 0.29 g of potassium hydroxide in solution in 6 cm3 of water and after treatment and recrystallization in diethyl ether, 1 g of (2R*,5S*)-3-{3-{2-[2-(3-hydroxyphenyl)-5-(3-methoxy-phenyl)-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoic acid, melting at 172° C., is obtained.

Provenance & Evidence