HCID 131719908, compound → HCID 19968242, compound

Participants

Reaction Steps

By proceeding in a fashion similar to that described in Example 9, but starting from 1.8 g of benzyl (2RS,5SR)-4-{3-{2-[2-(3-hydroxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetate in solution in 30 cm3 of methanol and 0.27 g of potassium hydroxide in solution in 6 cm3 of water, and after treatment and crystallization in diethyl ether, 0.5 g of (2RS,5SR)-4-{3-{2-[2(3-hydroxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetic acid, melting at 260° C., is obtained.

Provenance & Evidence