Potassium Bromide → Potassium Hydroxide

Participants

Reaction Steps

By proceeding in a fashion similar to that described in Example 9, but starting from 1.3 g of tert-butyl cis-{4-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}-phenylthio}acetate in solution in 20 cm3 of methanol and 0.17 g of potassium hydroxide in solution in 4 cm3 of water, and after treatment, 0.5 g of cis-{4-{3-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylthio}-acetic acid, melting at about 200° C., is obtained [proton NMR (200 MHz, DMSO D6, δ in ppm), 1.8 to 2.4 (m, 4H, CH2 --CH2); 3.35 (s, 2H, CH2S); 3.3 and 3.85 (ABX, 2H, CH2N): 5.1 (m, 2H, 2 CHN); 6.5 (t, 1H exchangeable, NH); 7.1 to 7.4 (m, 14H, aromatic); 9 (s, 1H exchangeable, NH)], [infrared spectrum (KBr), characteristic bands in cm-1 3400, 3090, 3060, 3030, 2975, 2875, 1640, 1595, 1540, 1495, 1450, 1400, 825, 760, 700].

Provenance & Evidence