HCID 86750540, compound → HCID 19968026, compound

Participants

Reaction Steps

By proceeding in a fashion similar to that described in Example 9, but starting from 0.8 g of ethyl (2RS,5SR)-3-{3-{2-[2-(2-hydroxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoate in solution in 15 cm3 of methanol and 0.27 g of potassium hydroxide in solution in 3 cm3 of water, and after treatment and recrystallization in diisopropyl ether, 0.21 g of (2RS,5SR)-3-{3-{2-[2-(2-hydroxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoic acid, melting at about 160° C., is obtained [proton NMR (200 MHz, DMSO D6, δ in ppm), 1.8 to 2.5 (2m, 4H, CH2 --CH2); 3.3 and 4 (ABX, 2H, CH2N); 5.2 (m, 2H, 2 CHN); 6.7 to 7.4 (m, 13H, aromatic); 6.8 (bt 9(s) 9.8(bs) 12.8(vbs) (4H exchangeable, 1 OH, 1 CO2H and 2NH)], [Infrared spectrum (KBr), characteristic bands in cm-1 3400, 3070, 2980, 1695, 1630, 1560, 1490, 1460, 760, 700, 685].

Provenance & Evidence