Methanol → HCID 86750543, compound

Participants

Reaction Steps

The operation is carried out in a fashion similar to that described in Example 9, but starting from 1.1 g of tert-butyl (2RS,5SR)-1-{2-[3-(3-ethoxycarbonylphenyl)ureido]acetyl}-5-(2-fluorophenyl)-prolinate in solution in 30 cm3 of methanol and 0.12 g of potassium hydroxide dissolved in 15 cm3 of water. After treatment and recrystallization in diisopropyl ether, 0.4 g of (2RS,5SR)-3-{3-{2-[2-tert-butoxy-carbonyl-5-(2-fluorophenyl)-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoic acid, melting at 180° C., is obtained.

Provenance & Evidence