Potassium Hydroxide → HCID 15788472, compound

Participants

Reaction Steps

The operation is carried out as in Example 9, but starting from 1.9 g of methyl (2S,5R)-3-{3-[2-(2-tert-butoxycarbonyl-5-phenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetate in solution in 60 cm3 of methanol and 0.22 g of potassium hydroxide dissolved in 30 cm3 of water. After treatment, 0.65 g of (2S,5R)-3-{3-[2-(2-tert-butoxycarbonyl-5-phenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetic acid, melting at 112° C., [α]D20 =+30.6°±0.8° (c=1; methanol) is obtained.

Provenance & Evidence