HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18928063, compound → tert-butyl (2RS,5RS)-1-{2-[3-(3-benzyloxycarbonylphenyl)ureido]-acetyl}-5-phenylprolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18928063 | HCID 18928063 | — |
| Reactant | Benzyl 3-isocyanatobenzoate | HCID 19700417 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-butyl (2RS,5RS)-1-{2-[3-(3-benzyloxycarbonylphenyl)ureido]-acetyl}-5-phenylprolinate | HCID 76139539 | 28.3% |
Reaction Steps
The operation is carried out in a fashion similar to that described in Example 2, but starting from 1.93 g of tert-butyl (2RS,5SR)-1-(2-aminoacetyl)-5-phenylprolinate and 3.61 g of benzyl 3-isocyanatobenzoate in 50 cm3 of tetrahydrofuran. After treatment, 1 g of tert-butyl (2RS,5SR)-1-{2-[3-(3-benzyloxycarbonylphenyl)-ureido]acetyl)-5-phenylprolinate, melting at 75° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05610144 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-1af4f31199c64f3bbbb8724b9e869da9 |
| Source note | uspto-grants-1997_03 |