HCID 131719914, compound → HCID 19967952, compound

Participants

Reaction Steps

The operation is carried out in a fashion similar to that described in Example 9, but starting from 0.55 g of tert-butyl (2RS,5SR)-1-{2-[3-(3-benzyloxycarbonylphenyl)-ureido]acetyl}-5-(2-pyridyl)prolinate in solution in 20 cm3 of methanol and 10 cm3 of 0.1N aqueous potassium hydroxide solution. After treatment, 0.17 g of (2RS,5SR)-3-{3-[2-(2-tert-butoxycarbonyl-5-(2-pyridyl)-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid, melting at 174° C., is obtained.

Provenance & Evidence