HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 57302214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | HCID 49851044 | HCID 49851044 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 57302214 | HCID 57302214 | 80.3% |
Reaction Steps
tert-Butyl (2S,5R)-1-(2-tert-butoxycarbonylaminoacetyl)-5-phenylprolinate may be obtained as per Example 2 B, but starting from a solution containing 8 g of tert-butyl (2S,5R)-5-phenylprolinate, 5.7 g of 2-tert-butoxycarbonylaminoacetic acid and 6.7 g of N,N'-dicyclohexylcarbodiimide in 75 cm3 of anhydrous acetonitrile. 10.5 g of tert-butyl (2S,5R)-1-(2-tert-butoxycarbonylaminoacetyl)-5-phenylprolinate, melting at 136° C., [α]D20 +19.1°±0.8° (C=0.64; methanol), are thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05610144 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-92089066b164476083efbce82256bf60 |
| Source note | uspto-grants-1997_03 |