反应详情

温度

20 °C

12 g (60 mmol) of dimethyl pyridine-2,5-dicarboxylate were suspended in 30 ml of glacial acetic acid and treated with 13 ml of hydrogen peroxide (35%) at 20° C. with stirring. The mixture was then heated with stirring to 100° C. (internal temperature), a clear solution being formed at 50° C. After the mixture had been stirred at 100° C. for 90 min, it was allowed to cool to 20° C., the crystalline precipitate was filtered off with suction and washed with water and, after drying, 7.5 g of product were obtained, m.p. 160° C. (dec.).

1. temperatureThe mixture was then heated
2. stirringwith stirring to 100° C. (internal temperature)
3. customa clear solution being formed at 50° C
4. stirringAfter the mixture had been stirred at 100° C. for 90 min
5. filtrationthe crystalline precipitate was filtered off with suction
6. washwashed with water
7. customafter drying