(E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline → N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)butanoyl]aniline

Participants

Reaction Steps

30 ml of ethanol and 0.1 g of platinum oxide were added to 0.24 g of (E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline, and the mixture was stirred at room temperature under a hydrogen stream for 45 minutes. After removing the solid by filtration, the solvent was removed by distillation and the obtained residue was applied to silica gel column chromatography to obtain 0.19 g of the title compound as white powder.

Provenance & Evidence