Acetic Anhydride → HCID 19968902, compound

HRID 976137Notes

Reaction equation

HRID 976137 reaction equation
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].OC1[C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([C:25](=[O:40])[CH2:26][CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)[CH2:29][CH2:28]4)=[CH:21][CH:20]=3)[C:12]=2[CH2:11]C1>C(Cl)(Cl)Cl>[C:5]([O:4][CH:1]1[C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH:18][C:19]3[CH:20]=[CH:21][C:22]([C:25](=[O:40])[CH2:26][CH:27]4[CH2:28][CH2:29][N:30]([CH2:33][C:34]5[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=5)[CH2:31][CH2:32]4)=[CH:23][CH:24]=3)[C:12]=2[CH2:11][CH2:2]1)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19968925HCID 19968925, compound

Product 1

HCID 19968902HCID 19968902, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

20 ml of chloroform and 0.65 ml of acetic anhydride were added to 0.35 g of N-(7-hydroxy-5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[(1-benzylpiperidin-4-yl)acetyl]aniline, and the mixture was refluxed under heating for 4 hours. Then, the solvent was removed by distillation under reduced pressure and the obtained residue was applied to silica gel column chromatography to obtain 0.16 g of the title compound as white crystal.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 4 hours
  3. customThen, the solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-aeff65827e034a80aaad4e02d9a077f2
Source dataset
uspto-grants-1997_03
Patent number
US05610303

Reaction notes

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