HCID 19968892, compound → HCID 19968938, compound

HRID 976148Notes

Reaction equation

HRID 976148 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:26])[CH:12]=[C:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(NC1C=CC(C(=O)CC2CCN(CC3C=CC=CC=3)CC=2)=CC=1)(=O)C>C(O)C.C1(C)C=CC=CC=1.[Pt]=O>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:26])[CH2:12][CH:13]2[CH2:14][CH2:15][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:17][CH2:18]2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 2

HCID 19968892HCID 19968892, compoundHCID 19968911HCID 19968911, compound

Product 1

HCID 19968938HCID 19968938, compound

Reagents, catalysts & solvents 3

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

In a mixed solution of 80 ml of ethanol and 30 ml of toluene was dissolved 7.10 g of the mixture of N-acetyl-4[(1-benzyl-4-piperidinyliden)acetyl]aniline and N-acetyl-4[(1-benzyl-1,2,5,6-tetrahydropyridin-4-yl)acetyl]aniline obtained in Reference example 14, and then 0.10 g of platinum oxide was added thereto. The mixture was stirred under a hydrogen stream for 5.5 hours. After the reaction, the catalyst was removed by filtration and condensed under reduced pressure. The residue obtained was applied to silica gel column chromatography to obtain 5.54 g of the title compound.

Workup

  1. customobtained in Reference example 14
  2. customAfter the reaction
  3. customthe catalyst was removed by filtration and condensed under reduced pressure
  4. customThe residue obtained

Sources & evidence

ORD record
ord-26247bcd8fb441a7b908fa18594bd9cb
Source dataset
uspto-grants-1997_03
Patent number
US05610303

Reaction notes

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