Tert-Butylamine → HCID 19966613, compound

Participants

Reaction Steps

2-Chloro-6-chlorosulfonylphenyl methanesulfonate was treated with t-butylamine and then base to give N-t-butyl 3-chloro-2-hydroxybenzenesulfonamide. Without purification, this material was nitrated using nitric acid in acetic acid to give N-t-butyl 3-chloro-2-hydroxy-5-nitrobenzenesulfonamide. Using sodium dithionite, this compound was reduced to give the aminophenol. The hydrochloride salt of this has also been prepared.

Provenance & Evidence