Toluene → HCID 19966771, compound

Participants

Reaction Steps

A round-bottomed flask (200 cc) equipped with a dropping funnel was charged with 4-chlorophenyl isocyanate (11.3 g, 73.7 mmol) and triethylamine (0.5 mL), as well as isopropyl ether (40 mL) and toluene (30 mL) and methacrolein cyanohydrin (8.94 g, 92.1 mmol) was dropwise added slowly with stirring at room temperature. After the addition, the mixture was stirred at room temperature for an additional 12 h. After completion of the reaction, the precipitating solids was recovered by filtration, washed with ether (5 mL×2) and hexane (5 mL×2) and subsequently dried to give 3-(4-chlorophenyl)-4-imino-5-isopropylideneoxazolidine-2-one (compound 3) as a white crystal (7.40 g; yield, 40.1%).

Provenance & Evidence