反应详情

100 mg (0.25 mmol) of N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine are dissolved in 1 ml of dimethyl sulfoxide, and 0.2 ml of ethylenediamine is added. After stirring for 22 h at 100°, the reaction mixture is concentrated and chromatographed (methylene chloride:methanol:concentrated ammonia solution=90:10:1). N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-[2-(2-amino-ethyl-amino)-4-pyridyl]-2-pyrimidineamine is obtained; FAB-MS: 423 (M+ +H), Rf =0.1 (methylene chloride:methanol:concentrated ammonia solution=90:10:1).

1. concentrationthe reaction mixture is concentrated
2. customchromatographed (methylene chloride:methanol:concentrated ammonia solution=90:10:1)