Dimethyl Sulfoxide → HCID 14373261, compound

Participants

Reaction Steps

A mixture of 2.3 parts of 6-(1-chloroethyl)-3,4-dihydro-2(1H)-quinolinone hydrochloride, 24 parts of acetonitrile, 7.7 parts of dimethyl sulfoxide and 3.8 parts of 1H-imidazole was stirred overnight at 60°-70° C. The reaction mixture was poured into water, extracted and further purified according similar procedures as described in example 12, yielding 1.2 parts (53.5%) of 3,4-dihydro-6-[1-(1H-imidazol-1-yl)ethyl]-2(1H)-quinolinone; mp. 184.8° C. (compound 21).

Provenance & Evidence