Acetonitrile → HCID 86750580, compound

Participants

Reaction Steps

The title compound was prepared from the product of step C (1.00g, 3.53 mmol) in a manner similar to example 1 step G with a modification in the purification. The residue was dissolved in acetonitrile and TFA (402 mg, 3.53 mmol) was added. The solvent was evaporated under reduced pressure and the residue redissolved in a minimal amount of acetonitrile. Addition of Et2O caused the precipitation of the crude product which was filtered and washed with Et2O. The material was briefly suspended in ice water, filtered, washed with ice water and dried. Recrystallization from acetonitrile afforded 720 mg (50%) of product as the TFA salt (m.p. 186°-187° C. dec.). Anal. calc'd. for C20N25O4F3 0.3H2O: C, 57.14; H, 6.15; N, 6.66.

Provenance & Evidence