2-Bromopropane → HCID 9992139, compound

Participants

Reaction Steps

5.4 g of 7-Hydroxy-6-isopropyl-1-tetralone was dissolved in 50 ml of N,N-dimethylformamide, followed by the addition of 7.3 g of potassium carbonate and 4.3 ml of 2-bromopropane. The obtained mixture was stirred for 8 hours under heating, cooled to room temperature by allowing to stand and extracted with ethyl acetate. The organic phase was washed with a saturated aqueous solution of common salt, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (developer: 5% ethyl acetate/n-hexane) to give 6.0 g of the title compound as a yellow oil.

Provenance & Evidence