Ethyl 10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]-benzodiazepine-7-carboxylate → HCID 21836976, compound

HRID 976375Notes

Reaction equation

HRID 976375 reaction equation
C1C=CN2CC3C=C(C(OCC)=O)C=CC=3NCC=12.[N+:20]([C:23]1[CH:36]=[C:35]([C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH:34]=[CH:33][C:24]=1[CH2:25][N:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[CH:31]=O)([O-])=O>>[CH:28]1[CH:29]=[CH:30][N:26]2[CH2:25][C:24]3[CH:33]=[CH:34][C:35]([C:37]([O:39][CH2:40][CH3:41])=[O:38])=[CH:36][C:23]=3[NH:20][CH2:31][C:27]=12

Participants

3

Reactant 2

HCID 21837067Ethyl 10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]-benzodiazepine-7-carboxylateHCID 21837109HCID 21837109, compound

Product 1

HCID 21836976HCID 21836976, compound

Procedure

The hydrogenation conditions of ethyl 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]-benzodiazepine-7-carboxylate are used with 1-[2-nitro-4-(ethoxycarbonyl)-benzyl]-pyrrole-2-carboxaldehyde to give 5.0 g of the desired product as a solid; mass spectrum (M+H)255.

Sources & evidence

ORD record
ord-82b1bbf438454d19812fbc46ffa28b76
Source dataset
uspto-grants-1997_03
Patent number
US05612334

Reaction notes

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